Social supports and serotonin transporter gene moderate depression in maltreated children.

By J. Kaufman, Bao-Zhu Yang, Heather Douglas-Palumberi, S. Houshyar, D. Lipschitz, John H. Krystal, Joel Gelernter. Proceedings of the National Academy of Sciences of the United States of America, 2004

806 citations recorded by the source corpus.

Subfields: Clinical Psychology

View Paper: https://www.semanticscholar.org/paper/b93fe9a86ee655ca6eee93316dd8ca2059dcf38e

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In Clinical Psychology

Citations in the corpus

DAT1 and 5HTT Are Associated With Pathological Criminal Behavior in a Nationally Representative Sample of Youth (2009, background): “Their findings were replicated using a racially diverse sample of children from Connecticut (including Hispanics, African Americans, and Whites; Kaufman et al., 2004).”
Intergenerational Trauma: Convergence of Multiple Processes among First Nations peoples in Canada (2009, positive): “Interestingly, it was shown that a genetic polymorphism (a gene mutation) will not necessarily result in expression of pathology, but may be evident provided that the individual had encountered a sufficiently severe stressful experience (Bradley et al., 2008; Caspi et al., 2003; Kaufman et al., 2004”
The stress response systems: Universality and adaptive individual differences (2006, background): “Korte et al. (2005) proposed a model of adaptive genetic variation in alternative Hawk–Dove phenotypes.”
Neurobiological and psychiatric consequences of child abuse and neglect. (2010, background): “Kaufman et al. (2004) demonstrated the importance of social support in further moderating the risk for depression in maltreated children with the s/s genotype.”
The link between childhood trauma and depression: insights from HPA axis studies in humans. (2008, positive): “The effect has been replicated in a recent twin study (Kendler et al., 2005) as well as in maltreated children (Kaufman et al., 2004, 2006).”
Loneliness Across the Life Span (2015, background): “For example, the serotonin transporter gene increases vigilance to social threat, but it also increases interpersonal sensitivity (Fiedorowicz et al., 2007) and shows strong associations with social support and mood state (Kaufman et al., 2004; Van Roekel et al., 2010).”
Psychobiology and molecular genetics of resilience (2009, neutral): “Social support seems to mitigate the effects of the short allele of 5 - HTTLPR”