Half-Life of Serum Elimination of Perfluorooctanesulfonate,Perfluorohexanesulfonate, and Perfluorooctanoate in Retired Fluorochemical Production Workers
By G. Olsen, J. Burris, D. Ehresman, John W. Froehlich, A. Seacat, J. Butenhoff, L. R. Zobel. Environmental Health Perspectives, 2007
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Background The presence of perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate (PFHS), and perfluorooctanoate (PFOA) has been reported in humans and wildlife. Pharmacokinetic differences have been observed in laboratory animals. Objective The purpose of this observational study was to estimate the elimination half-life of PFOS, PFHS, and PFOA from human serum. Methods Twenty-six (24 male, 2 female) retired fluorochemical production workers, with no additional occupational exposure, had periodic blood samples collected over 5 years, with serum stored in plastic vials at −80°C. At the end of the study, we used HPLC-mass spectrometry to analyze the samples, with quantification based on the ion ratios for PFOS and PFHS and the internal standard 18O2-PFOS. For PFOA, quantitation was based on the internal standard 13C2-PFOA. Results The arithmetic mean initial serum concentrations were as follows: PFOS, 799 ng/mL (range, 145–3,490); PFHS, 290 ng/mL (range, 16–1,295); and PFOA, 691 ng/mL (range, 72–5,100). For each of the 26 subjects, the elimination appeared linear on a semi-log plot of concentration versus time; therefore, we used a first-order model for estimation. The arithmetic and geometric mean half-lives of serum elimination, respectively, were 5.4 years [95% confidence interval (CI), 3.9–6.9] and 4.8 years (95% CI, 4.0–5.8) for PFOS; 8.5 years (95% CI, 6.4–10.6) and 7.3 years (95% CI, 5.8–9.2) for PFHS; and 3.8 years (95% CI, 3.1–4.4) and 3.5 years (95% CI, 3.0–4.1) for PFOA. Conclusions Based on these data, humans appear to have a long half-life of serum elimination of PFOS, PFHS, and PFOA. Differences in species-specific pharmacokinetics may be due, in part, to a saturable renal resorption process.
Subfields: Environmental Chemistry, Public Health, Environmental and Occupational Health, Water Science and Technology
View Paper: https://www.semanticscholar.org/paper/b91cd22d51058aef91c0eedbcff0ddeb8dd12b10
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Citations in the corpus
- Perfluorinated compounds--exposure assessment for the general population in Western countries. (2009, background): “Currently, the time trend of the internal exposure in the general population has been investigated in some studies (Harada et al., 2004; Olsen et al., 2005, 2007a; Jin et al., 2007; Harada et al., 2007a; Wilhelm et al., 2008b).”
- Perfluoroalkyl acids: a review of monitoring and toxicological findings. (2007, background): “(Olsen et al. , 2006, 2007a).”
- Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort (2007, background): “PFOA and PFOS are slowly metabolized and have half-lives in humans around 4 years and 5 years, respectively (Olsen et al. 2007).”
- Uptake, accumulation and metabolism of PFASs in plants and health perspectives: A critical review (2020, background): “The elimination half-lives for PFOA and PFOS in humans were estimated to be 8 years and 5.4 years, respectively (Olsen et al., 2007).”
- Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers among Adults Living Near a Chemical Plant (2013, background): “After employment ended, exposure estimates decayed at a rate of 18% per year based on a presumed half-life of 3.5 years (Olsen et al. 2007).”
- Epidemiologic Evidence on the Health Effects of Perfluorooctanoic Acid (PFOA) (2010, neutral): “Its half-life has been estimated at 5.4 years (Olsen et al. 2007a).”
- Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research (2020, background): “Available studies on PFBS, PFHxS, perfluorohexanoic acid, PFNA and PFDA suggest that they share molecular targets with similar consequences, albeit with differences in potency, in part due to differences in their excretion and protein‐interaction kinetics (Zeilmaker et al. 2018).”