Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort
By Chunyuan Fei, J. Mclaughlin, R. Tarone, Jorn Olsen. Environmental Health Perspectives, 2007
628 citations recorded by the source corpus.
Background Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are man-made, persistent organic pollutants widely spread throughout the environment and human populations. They have been found to interfere with fetal growth in some animal models, but whether a similar effect is seen in humans is uncertain. Objectives We investigated the association between plasma levels of PFOS and PFOA in pregnant women and their infants’ birth weight and length of gestation. Methods We randomly selected 1,400 women and their infants from the Danish National Birth Cohort among those who completed all four computer-assisted telephone interviews, provided the first blood samples between gestational weeks 4 and 14, and who gave birth to a single live-born child without congenital malformation. PFOS and PFOA were measured by high performance liquid chromatography–tandem mass spectrometer. Results PFOS and PFOA levels in maternal plasma were on average 35.3 and 5.6 ng/mL, respectively. Only PFOA levels were inversely associated with birth weight (adjusted β = −10.63 g; 95% confidence interval, −20.79 to −0.47 g). Neither maternal PFOS nor PFOA levels were consistently associated with the risk for preterm birth or low birth weight. We observed no adverse effects for maternal PFOS or PFOA levels on small for gestational age. Conclusion Our nationwide cohort data suggest an inverse association between maternal plasma PFOA levels and birth weight. Because of widespread exposure to these chemicals, our findings may be of potential public health concern.
Subfields: Environmental Chemistry, Health, Toxicology and Mutagenesis, Water Science and Technology
View Paper: https://www.semanticscholar.org/paper/f65725effde42bf4b9fc32542cf3e6d76a107492
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Citations in the corpus
- Perfluorinated compounds--exposure assessment for the general population in Western countries. (2009, background): “In a nationwide study, the Danish National Birth cohort, 1400 randomly selected women provided blood samples between gestational weeks 4 and 14 (Fei et al., 2007).”
- Epidemiologic Evidence on the Health Effects of Perfluorooctanoic Acid (PFOA) (2010, neutral): “…weight (< 2,500 g) was elevated in the upper three quartiles relative to the first quartile in the analysis of the Danish National Birth Cohort (Fei et al. 2007), but a measure of small-for-gestational-age (which accounts for duration of gestation) was not related to PFOA in the Danish…”
- Perfluoroalkyl and polyfluoroalkyl substances: current and future perspectives (2011, background): “A further study reported a statistically significant negative correlation between abdominal circumference and maternal PFOA, a statistically significant positive association between ponderal index to maternal PFOA of women who were obese before pregnancy, and a statistically non-significant negative”
- Advances in barrier coatings and film technologies for achieving sustainable packaging of food products – A review (2021, background): “Starting in 2015 some long-chain PFASs have begun being regulated or phased out due to their health risk issues with kidney, cancer, and thyroid related diseases (Barry et al., 2013; Fei et al., 2007; Stein et al., 2009).”