Systems Biology of Cancer Metastasis

By Yasir Suhail, Margo P. Cain, Kiran Vanaja Gireesan, Paul Kurywchak, Andre Levchenko, Raghu Kalluri, Kshitiz. Cell Systems, 2019

361 citations recorded by the source corpus.

Cancer metastasis is no longer viewed as a linear cascade of events, but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. Lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for metastatic disease. Because metastasis has traditionally been investigated in distinct physiological compartments, the integration of these complex and interlinked aspects remains a challenge for both systems-level experimental and computational modeling of metastasis. Here, we present some of the current perspectives on the complexity of cancer metastasis, the multi-scale nature of its progression, and a systems-level view of the processes underlying the invasive spread of cancer cells. We also highlight the gaps in our current understanding of cancer metastasis as well as insights emerging from interdisciplinary systems biology approaches to understand this complex phenomenon.

Subfields: Education, Literature and Literary Theory

View Paper: https://www.semanticscholar.org/paper/813393ab07a672f4f36c65ba02d9b13b545bb6c9

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Citations in the corpus

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “Another widely held belief is that metastasis results from the spread of a malignant lesion through the activation of cellular reprogramming by microenvironmental stressors that promotes cell invasion and migration [93, 94].”