The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry

By Trevor W. Robbins. Psychopharmacology, 2002

1,291 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/b8373dfd887d82c5289b4667b88490c5e2e0b9da

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

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Citations in the corpus

Decision making, the P3, and the locus coeruleus-norepinephrine system. (2005, background): “Together, these findings and the well-documented role of the cholinergic system in the regulation of attention (e.g., Robbins, 2002) indicate that future research needs to explore the distinct contributions of NE and acetylcholine as well as interactions between these systems in P3 generation…”
Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models (2014, methodology): “The ﬁve choice serial reaction time task (5-CSRTT) is a behavioral task that measures the response inhibition component of executive function (5-CSRTT is also used to model aspects of attention, see below section) in mice (Robbins, 2002; Bari et al., 2008; Chudasama, 2011; Romberg et al., 2013a).”
Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization (2006, methodology): “The five-choice serial reaction time task (5-CSRTT) is a well-validated rodent model of attention that requires the detection of a signal light presented randomly in one of five locations during 30-min sessions (Robbins 2002).”
A delay-discounting primer. (2010, background): “For example, failure of attention (e.g., Robbins, 2002), inability to inhibit pre-potent responses (e.g., Winstanely et al., 2005), and the devaluation of future events (e.g., Ainslie, 1975) have received much attention.”
Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates. (2004, background): “Neuromodulatory influences The ascending monoaminergic (NA, DA and 5-HT) and cholinergic (ACh) systems contribute to different aspects of performance on the 5-CSRTT [113].”
Impulsivity, compulsivity, and top-down cognitive control. (2011, neutral): “However, motivational factors do not appear primary; although 5CSRTT impulsivity can be reduced by satiety (Robbins, 2002), the latencies to collect earned rewards are no faster than in low-impulsive rats (Dalley et al., 2007).”
The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats (2008, methodology): “41" language="eng" publish="issue" relation="no"> Introduction The 5-choice serial reaction time task (5-CSRTT) was initially developed to investigate and better understand the deficits shown by children with attention deficit/hyperactivity disorder (ADHD) at a preclinical leve”
Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review (2010, methodology): “A third component comprises insufficient information sampling before making a choice, measured by information sampling tasks such as the Reflection Task (Clark et al, 2006) and possibly the 5-Choice Serial Reaction Time Task (5-CSRTT) (Robbins, 2002) (Table 1).”
Neurochemistry of Visual Attention (2021, background): “…activity seems to play an especially important role in prepotent response inhibition and impulsivity with less impact on attentional processing (Robbins, 2002; Brown et al., 2012; Worbe et al., 2014), it also seems to have some influence on attentional processing (Carter et al., 2005; Scholes…”