Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization

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Anxiolytic effects of nicotine in zebrafish. (2007, background): “A dose–effect nicotine study on zebrafish in a delayed alternation task [16] found results consistent with rats, monkeys, and humans [19]: low doses improve memory, while high doses are detrimental.”
Meta-analysis of the acute effects of nicotine and smoking on human performance (2010, background): “…and nicotinic ligands have been tested as treatments for several neuropsychiatric disorders, including schizophrenia, attention deficit/hyperactivity disorder, Alzheimer's and Parkinson's diseases, and age-related cognitive decline (Evans and Drobes 2008; Levin et al. 2006; Newhouse et al. 2004).”
Resting state functional connectivity in addiction: Lessons learned and a road ahead (2012, background): “, 2007) and, additionally, may hold therapeutic utility for other disease states involving attentional dysfunction (Levin et al., 2006).”
The role of acetylcholine in learning and memory. (2006, background): “Conversely, drugs that activate nicotinic receptors enhance the encoding of new information [4,5].”
Modes and Models of Forebrain Cholinergic Neuromodulation of Cognition (2010, background): “The investigation of the cognitive effects of nicotine has given rise to an enormously productive field of research on the cognitive functions of nAChRs (eg, Warburton and Mancuso, 1998; Stolerman et al, 2000; Levin et al, 1998; Levin et al, 2006).”