In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space.
By R. Thorne, C. Nicholson. Proceedings of the National Academy of Sciences of the United States of America, 2006
621 citations recorded by the source corpus.
Subfields: Biophysics, Cognitive Neuroscience, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/b7f61fc63f54f054d213fd7f77ec6cfb9ccdbc12
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In Biophysics
In Cognitive Neuroscience
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment. (2014, background): “Particles with a size of less than 50 nm and a neutral or negative charge are crucial for disposition of nanoparticles in the brain [139].”
- Diffusion in Brain Extracellular Space (2008, positive): “In the first study to employ QDs to explore the ECS, Thorne and Nicholson (391) (Fig.”
- PEGylation as a strategy for improving nanoparticle-based drug and gene delivery (2015, positive): “Using intravital imaging in the rat brain to assess the diffusional spread of commercially available PEGylated quantum dots (QDs), it was previously determined that the brain ECM contained pores with diameters ranging from 38-64 nm [168].”
- The blood-brain barrier: an engineering perspective (2013, background): “Analysis of in vivo experiments using probes with different hydrodynamic radii suggests effective pore dimensions of about 40 nm between parallel plates and about 60 nm for cylindrical channels (Thorne et al., 2005; Thorne and Nicholson, 2006).”
- Intranasal delivery of biologics to the central nervous system. (2012, background): “This suggested to the authors that IN [(131)I]-Ex was transported by a bulk flow mechanism (energy dependent) rather than diffusion, although reduction of the brain extracellular space following terminal ischemia would also have likely altered diffusion, complicating interpretation of the data [78].”