Self-renewal and solid tumor stem cells

By M. Al-Hajj, M. Clarke. Oncogene, 2004

987 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/b7ee91201290b5e0e9e01d10ed5916804211459c

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In Cell Biology

1. Linheng Li

In Molecular Biology

1. Linheng Li
2. Richard J. Gilbertson
3. W. Neaves
4. A. Puisieux
5. R. Weinberg
6. Pengfei Lu
7. K. Turksen

In Oncology

1. Linheng Li
2. Richard J. Gilbertson
3. W. Neaves
4. A. Puisieux
5. R. Weinberg

Citations in the corpus

• Normal stem cells and cancer stem cells: the niche matters. (2006, background): “In this sense, cancer may prove to be more of a stem cell disease than previously suspected (13, 15).”
• CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells (2008, background): “Such cells have been termed cancer stem cells and are defined by their capacity to self-renew, express stem cell markers and to initiate tumors in vivo.(1,2) Potential cancer stem cells have been identified in leukaemias, breast,(6) prostate,(7) bone,(8) colon and brain cancer.”
• Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment (2009, background): “According to this model, tumor can be viewed as a result of abnormal organogenesis driven by CSCs, defined as self-renewing tumor cells able to initiate and maintain the tumor and to produce the heterogeneous lineages of cancer cells that compose the tumor (4, 5).”
• Meeting highlights: international expert consensus on the primary therapy of early breast cancer 2005. (2005, result): “Biology of cancer cells with special/unique metastatic potential: new targets for therapy The hypothesis that a subset of tumor cells (‘tumor stem cells’) are responsible for invasion and metastases, while other tumor cells are not tumorigenic, is supported by experiments on human breast cancer cell”
• From antimicrobial to anticancer peptides. A review (2013, background): “The tumor masses are represented by phenotypically heterogeneous populations of cancer cells, each having its own ability in proliferating and forming a new tumor (Reya et al., 2001; Al-Hajj and Clarke, 2004).”
• Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition (2008, background): “This signature, termed IGS (for invasiveness gene signature), has been generated by the Clarke group by comparing the gene-expression profiles of CD242 breastcancer cells and normal breast epithelium.”
• Radial glia cells are candidate stem cells of ependymoma. (2005, background): “While cancer stem cells have been isolated from solid tumors of the brain and breast, the relationship of these cells to normal progenitors in the respective tissues of origin is unknown (Al-Hajj and Clarke, 2004; Singh et al., 2004a).”