Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer.

By B. Carver, Caren Chapinski, John Wongvipat, H. Hieronymus, Yu Chen, S. Chandarlapaty, V. Arora, Carl H. Le, J. Koutcher, H. Scher and 3 more. Cancer Cell, 2011

1,201 citations recorded by the source corpus.

Subfields: Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/b7d92cb98f98b4844340d4ccc39d44d04587497d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Hans Clevers
2. H. Begthel
3. R. DePinho
4. Arul M. Chinnaiyan
5. R. Vries
6. J. Drost
7. Edwin Cuppen
8. Stephen B. Gruber

In Pulmonary and Respiratory Medicine

1. Arul M. Chinnaiyan
2. John Wongvipat
3. R. Vessella
4. Hans Clevers
5. C. Sawyers

Citations in the corpus

• Personalized Oncology Through Integrative High-Throughput Sequencing: A Pilot Study (2011, background): “Recent data suggest that combined blockade of these two pathways may provide additional benefit over single-agent therapy (22).”
• Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines (2012, background): “AR-Vs have been reported to induce unique transcriptional targets such as AKT1 (9), which may play a role in enzalutamide resistance (17).”
• Organoid cultures derived from patients with advanced prostate cancer (2014, neutral): “PTEN loss has been functionally associated with castration resistance (Carver et al., 2011) and loss of PTEN function through copy number loss (blue), mutation (green), or decreased expression is common in CRPC (30/36 samples) but only in 10% of primary cancer (Figure 5C and data not shown) (Baca…”
• Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling (2017, background): “Phosphatidylinositol 3-kinase (PI3K)/AKT signaling can influence the progression of CRPC and effectively compensate for reduced AR activity in PC models via reciprocal feedback activation (Carver et al., 2011; Mulholland et al., 2011).”
• Identification of multipotent luminal progenitor cells in human prostate organoid cultures (2014, background): “…hyperactive PI3K signaling in Pten null prostate tissue results in reduced Ar transcriptional activity due to negative feedback on Her kinase signaling(Carver et al., 2011), we observed reduced expression of the Ar target genes Psca and Fkbp5 in organoids with Pten knockdown (Figures 3C and S3D).”
• ARN-509: a novel anti-androgen for prostate cancer treatment (2012, neutral): “, phosphoinositide 3kinase (PI3K)] in prostate tumorigenesis (16).”
• Genetics and biology of prostate cancer (2018, background): “Indeed, combined inhibition of PI3K/AKT and AR signaling can provoke robust regressions in Pten-deficient GEMMs and human PDX models (Carver et al. 2011; Mulholland et al. 2011).”