Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases

By R. Casero, L. Marton. Nature reviews. Drug discovery, 2007

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Mammalian Polyamine Metabolism and Function (2009, background): “Polyamine response elements have been identified in some genes (5, 10) and the transcription of many genes”
Higher polyamines restore and enhance metabolic memory in ripening fruit (2008, background): “Interest in polyamine research has further intensified because of their (and polyamine analogs’) potential involvement and implications in such diverse disciplines as oncology [6], obesity [7], gastroenterology [8], cerebral stroke and other disorders [9], parasitology [10], oxidative stress [9,11,1”
Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles (2009, background): “For example, polyamines are correlated with cell growth and proliferation ( Casero and Marton 2007; Gerner and Meyskens 2004; Tabor and Tabor 1984), and with tumor growth in oral cancer (Dimery et al. 1987), while putrescine is used to monitor the effect of chemotherapy on oral cancer cells (Okamur”
Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses (2016, background): “They consist of putrescine, spermidine, and spermine, and their levels are tightly controlled and regulated by enzymes involving polyamine biosynthesis, catabolism, and transport (23).”