Mammalian Polyamine Metabolism and Function

By A. E. Pegg. IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2009

761 citations recorded by the source corpus.

Polyamines are ubiquitous small basic molecules that play multiple essential roles in mammalian physiology. Their cellular content is highly regulated and there is convincing evidence that altered metabolism is involvement in many disease states. Drugs altering polyamine levels may therefore have a variety of important targets. This review will summarize the current state of understanding of polyamine metabolism and function, the regulation of polyamine content, and heritable pathological conditions that may be derived from altered polyamine metabolism. © 2009 IUBMB IUBMB Life 61(9): 880–894, 2009

Subfields: Biochemistry, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/23b19c28acadb8184aebe7a6aa5d993ea85caf85

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Guido Kroemer
2. T. Eisenberg
3. F. Pietrocola
4. Frank Madeo
5. A. E. Pegg
6. M. Munder

In Molecular Biology

1. F. Pietrocola
2. Frank Madeo
3. Guido Kroemer
4. T. Eisenberg
5. A. E. Pegg
6. M. Munder
7. L. Galluzzi
8. Douglas R. Green

In Pharmacology

1. Guido Kroemer
2. A. E. Pegg
3. F. Pietrocola
4. Beth Levine

Citations in the corpus

• Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages (2014, background): “Polyamines are small, polycationic molecules, which regulate a multitude of cellular processes like DNA replication, protein translation, cell growth, and differentiation (69, 70).”
• Functions of Polyamines in Mammals* (2016, background): “The polyamine biosynthetic and interconversion pathway in mammals is well established and has been described in multiple reviews (5, 6).”
• ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “N-Acetyl-3-aminopropanaldehyde and H2O2 are produced as by-products of these reactions [94, 96].”
• Spermidine in health and disease (2018, background): “1) in tightly regulated step-wise reactions (20, 22, 29).”