A trafficking checkpoint controls GABA(B) receptor heterodimerization.
By M. Margeta-Mitrovic, Y. Jan, L. Jan. Neuron, 2000
711 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/b78ca3f6180373870371c38a1f08376061d104be
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In Cellular and Molecular Neuroscience
- Leslie B. Vosshall
- Michel Bouvier
- B. Bettler
- Walton D. Jones
- Richard Benton
- R. Stocker
- Brian K. Kobilka
- Carolina Gomez-Diaz
In Molecular Biology
Citations in the corpus
- Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction. (2004, methodology): “Full-length Or22a cDNA was cloned into pUAST via(Margeta-Mitrovic et al., 2000).”
- Bi-directional protein transport between the ER and Golgi. (2004, background): “Individual subunits of a number of oligomeric cell surface receptors and channels possess ER retrieval motifs that are masked when the holocomplex is correctly assembled (Letourneur et al. 1995, Mallabiabarrena et al. 1992, Margeta-Mitrovic et al. 2000).”
- Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. (2002, background): “However, the results of several studies (41, 61, 62) showing that mutation or truncation of an ER retention signal, within the carboxyl tail of the GABAb R1, was sufficient to allow cell surface targeting of GABAb R1 even in the absence of GABAb R2, but not to generate a functional receptor seriousl”
- Molecular Structure and Physiological Functions of GABAB Receptors (2004, background): “Mutational analysis confirmed that the COOH-terminal coiled-coil interaction of GABAB receptors is essential for surface trafficking of the heteromer (57, 210, 250).”
- International Union of Pharmacology. XXXIII. Mammalian γ-Aminobutyric AcidB Receptors: Structure and Function (2002, methodology): “The GABAB2 protein not only serves to escort GABAB1 to the cell surface, it appears to be the receptor component that links to the G protein, whereas the GABAB1 subunit is necessary for agonist activation (Margeta-Mitrovic et al., 2000; Calver et al., 2001; Galvez et al., 2001; Pagano et al., 2001).”