Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

By S. Sigurdsson, G. Nordmark, H. Göring, K. Lindroos, Ann-Christin Wiman, G. Sturfelt, A. Jönsen, S. Rantapää-Dahlqvist, B. Möller, J. Kere and 9 more. American Journal of Human Genetics, 2005

644 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/b7062b892d94e445b866a8d06adf1282e9133bee

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Citations in the corpus

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus (2006, background): “Here we convincingly replicate association of the IFN regulatory factor 5 ( IRF5 ) rs2004640 T allele with SL”
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci (2010, background): “8 × 10 −6 ), chosen because of its association with SL”
Toll-like receptors in systemic autoimmune disease (2006, background): “Remarkably, studies of five separate patient cohorts have now identified at least two SNPs associated with IRF5 as being high risk factors for SLE 88, 89 .”
The JAK/STAT signaling pathway: from bench to clinic (2021, background): “Cytokines play a central role in the pathogenesis of SLE.278,279 A wide range of cytokines are considered immunopathological in Signal Transduction and Targeted Therapy (2021) 6:402 the initiation and development of human SLE, such as IFNs, TNF, IL-6, IL-10, and IL-12.”
JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects (2017, background): “For example, JAK2 polymorphisms are associated with Behçet’s disease, while single nucleotide polymorphisms in the TYK2 gene have been implicated in Crohn’s disease (CD) and lupus [25, 60, 61].”