Targets of the cyclin-dependent kinase Cdk1

By Jeffrey A. Ubersax, E. L. Woodbury, P. Quang, M. Paraz, Justin D. Blethrow, Kavita Shah, Kevan M. Shokat, D. Morgan. Nature, 2003

984 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/b669bafc79141ddeba2c44ff65b32154793a7266

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In Cell Biology

1. Matthias Mann
2. J. Thorner
3. H. Bussey
4. Jüergen Cox
5. Raymond E. Chen
6. G. Lesage
7. J. Ferrell

In Molecular Biology

1. Jüergen Cox
2. Stefka Tyanova
3. Matthias Mann
4. Christoph Schaab
5. Jacek R. Wisniewski
6. K. Sharma
7. Rochelle C. J. D’Souza
8. G. Lesage

In Oncology

1. Matthias Mann
2. Jacob C. Harrison
3. K. Lu
4. J. Haber
5. J. Ferrell

Citations in the corpus

• Surviving the breakup: the DNA damage checkpoint. (2006, background): “are over 200 in vitro targets of Cdk1 phosphorylation (144), including Mre11 and Xrs2, but”
• Prolyl cis-trans isomerization as a molecular timer. (2007, background): “However, given that Cdks often phosphorylate many substrates (for example, several hundred proteins are phosphorylated by Cdc2 during the G2/M transitio”
• TARGETING CDK4 AND CDK6: FROM DISCOVERY TO THERAPY (2015, neutral): “Unlike CDKs 1 and 2 that phosphorylate many hundreds of cellular protein substrates (13), CDK4 is a surprisingly fastidious enzyme that has a restricted propensity to phosphorylate the retinoblastoma protein (RB1, hereafter RB) and two other RB-family proteins [RB2 (p130), RBL1 (p107); refs.”
• Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. (2014, background): “A table of kinases and their KM values (Donella-Deana et al., 2005; Fan et al., 2005; Sarno et al., 1996; Ubersax et al., 2003).”
• Mechanisms of specificity in protein phosphorylation (2007, background): “Systematic in vitro proteomic studies in Saccharomyces cerevisiae support this proposal: in one study, kinases phosphorylated between 1 and 256 substrates, and in a second study, cyclin-dependent kinase-1 ( Cdk1 ) from yeast phosphorylated hundreds of substrate”
• Cell Wall Assembly in Saccharomyces cerevisiae (2006, background): “However, the observation that Chs2 is a substrate for Clb2-activated Cdc28 suggests a possible means of regulation of Chs2 level and/or activity during the cell cycle (285).”
• Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs (2009, background): “We also investigated the CDK site-containing NLSs from the top 200 substrates of CDK1 in yeast (24) and 35 CDK1 substrates identified by a proteomic study (25), and found 14 proteins carrying a CDK-site-containing NLS with a score of 4 (Table S3).”
• Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. (2007, background): “Cell cycle-specific control of Tus1 via its phosphorylation by two protein kinases, Cdc28/ Cdk1 [114] and Cdc5 (ortholog of mammalian Polo kinase) [115], and the resulting local activation of Rho1 is important for the events necessary for actin contractile ring assembly for cytokinesis.”