Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies
By B. Haynes, J. Fleming, E. S. St Clair, H. Katinger, G. Stiegler, R. Kunert, James E. Robinson, R. Scearce, K. Plonk, H. Staats and 3 more. Science, 2005
771 citations recorded by the source corpus.
Subfields: Molecular Biology, Radiology, Nuclear Medicine and Imaging, Virology
View Paper: https://www.semanticscholar.org/paper/b63d6ed9b56edb8a0a4e337e19fa65591af63e05
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Citations in the corpus
- Translating innate immunity into immunological memory: implications for vaccine development. (2006, positive): “A counterpoint to understanding the influence of innate immunity in memory T cell generation is to appreciate how several pathogens, particularly those that cause chronic infections such as HIV, HCV, and TB, can interfere with this process to induce dysfunctional T cells.”
- Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells (2008, background): “To exclude the possibility that the antibodies cross-reactive properties extended to autoreactivity as has been described for several broadly neutralizing HIV mAbs [33] they were screened by immunohistochemistry on a panel of 32 human tissues.”
- Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8 (2016, background): “Were they generated in response to other non-HIV-1 antigens [18]? Were the initial B cell recombinants polyreactive [19]? Or did the membrane-reactivity arise through somatic hypermutation (SHM) in the periphery, where autoreactivity checkpoints are less stringent [20]? To address these questions, w”