SARS-CoV-2: A Storm is Raging.
By Savannah F. Pedersen, Y. Ho. Journal of Clinical Investigation, 2020
1,029 citations recorded by the source corpus.
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunologic characteristics between moderate versus severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10 and TNFα), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFNγ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.
Subfields: Infectious Diseases, Neurology
View Paper: https://www.semanticscholar.org/paper/b999b0f79272e58a6e0806ce5903adc4357889f4
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In Neurology
Citations in the corpus
- SARS-CoV-2 infection: The role of cytokines in COVID-19 disease (2020, neutral): “Various authors have detected this interleukin in patients with COVID-19 and related its levels to disease severity and progression, as in the case of other cytokines [17,43,57,64,82,83,86,88,89] and it has been reported to have possible prognostic value [54].”
- Neutrophil extracellular traps in COVID-19. (2020, background): “(ARDS) and even multiorgan failure in some individuals (2).”