Molecular immune pathogenesis and diagnosis of COVID-19

By Xiaowei Li, Manman Geng, Yizhao Peng, L. Meng, Shemin Lu. Journal of Pharmaceutical Analysis, 2020

1,536 citations recorded by the source corpus.

Coronavirus disease 2019 (COVID-19) is a kind of viral pneumonia which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The emergence of SARS-CoV-2 has been marked as the third introduction of a highly pathogenic coronavirus into the human population after the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) in the twenty-first century. In this minireview, we provide a brief introduction of the general features of SARS-CoV-2 and discuss current knowledge of molecular immune pathogenesis, diagnosis and treatment of COVID-19 on the base of the present understanding of SARS-CoV and MERS-CoV infections, which may be helpful in offering novel insights and potential therapeutic targets for combating the SARS-CoV-2 infection.

Subfields: Infectious Diseases, Modeling and Simulation

View Paper: https://www.semanticscholar.org/paper/535ae4b3525c0a104b007f190fcce59de617a56e

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Citations in the corpus

• Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response (2020, positive): “The formation of these vesicles causes shield recognition of cytosolic PRRs to dsRNA as an intermediate product of replication virus [28].”
• Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment (2020, background): “In some patients, this activation becomes so massive that cytokine storm develops, resulting in thrombotic tendency and multi-organ failure, and eventually causing death [5, 6].”
• Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis (2020, background): “The prevalence of GGOs observed in early phases of the disease in our patient’s series likely represents the imaging correlate of the acute-phase diffuse alveolar damage that has reported, with airspace edema, bronchiolar fibrin, and interstitial thickening [17].”
• COVID-19: Transmission, prevention, and potential therapeutic opportunities (2020, neutral): “Moreover, inhibitors of the IL-1 family, IFN-γ cytokines, and the Janus kinase signal transducer and activator of transcription proteins (JAKSTAT) signaling pathway might also be useful for controlling the cytokine storm [120].”
• DHP Framework: Digital Health Passports Using Blockchain - Use case on international tourism during the COVID-19 pandemic (2004, methodology): “The latter is motivated by the fact that the RT-qPCR method (the main diagnostic method for COVID-19 by May 2020) can only achieve a sensitivity between 50% and 79% [38] and therefore, at the time of writing, additional methods are being researched.”