The in vivo degradation, absorption and excretion of PCL-based implant.
By Hongfan Sun, Lin Mei, Cunxian Song, X. Cui, Pengyan Wang. Biomaterials, 2006
950 citations recorded by the source corpus.
Subfields: Biomaterials, Biomedical Engineering, Surgery
View Paper: https://www.semanticscholar.org/paper/b5b58c6426c862b1154930b1bbc1b3c504b9933a
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In Biomaterials
- P. S. Wolfe
- Gustavo A. Abraham
- I. Rodriguez
- S. Sell
- Koyal Garg
- G. Gotelli
- A. Sosnik
- Jennifer M. McCool
In Biomedical Engineering
In Surgery
Citations in the corpus
- Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful (2011, background): “PCL withstands ydrolysis better than PGA and PLA [64,65] and sustains he release of the encapsulated drugs for longer times 66].”
- Bone tissue engineering: A review in bone biomimetics and drug delivery strategies (2009, background): “This is assigned in part to the optimum concentration of esterdegrading enzymes such as lipases in the human body.(232,237,238) To mimic the in vivo environment, many researchers utilize bacterial enzymes such as Pseudomonas cepacia lipase at higher than physiologic concentrations.”
- Physicochemical characterisation of degrading polycaprolactone scaffolds (2010, background): “PCL is commonly referred to as a “biodegradable” polyester [3,4] and whilst this material is known to breakdown in vivo, the breakdown products form naturally occurring metabolites, which are readily metabolised by the body and eliminated without toxicity.”
- The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues (2010, background): “PCL can last within the body for more than 2 years [130].”
- A review on powder-based additive manufacturing for tissue engineering: selective laser sintering and inkjet 3D printing (2015, methodology): “Sun et al [51] conducted a long termdegradation study in vivo in rats using radio-labeled PCL and after 2 years of in vivo implantation, PCL maintained its form while the molecular weight decreased.”
- 4D Printing Technology: A Review (2015, positive): “28 While Morrison et al. printed the supporting structure with a customized design for patients less than 1 year old, the splint accommodated changes in airway size by expanding as the patient grew for 3 years as shown in Figure 4.”