The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues
By S. Sell, P. S. Wolfe, Koyal Garg, Jennifer M. McCool, I. Rodriguez, G. Bowlin. 2010
540 citations recorded by the source corpus.
Abstract: Natural polymers such as collagens, elastin, and fibrinogen make up much of the body’s native extracellular matrix (ECM). This ECM provides structure and mechanical integrity to tissues, as well as communicating with the cellular components it supports to help facilitate and regulate daily cellular processes and wound healing. An ideal tissue engineering scaffold would not only replicate the structure of this ECM, but would also replicate the many functions that the ECM performs. In the past decade, the process of electrospinning has proven effective in creating non-woven ECM analogue scaffolds of micro to nanoscale diameter fibers from an array of synthetic and natural polymers. The ability of this fabrication technique to utilize the aforementioned natural polymers to create tissue engineering scaffolds has yielded promising results, both in vitro and in vivo , due in part to the enhanced bioactivity afforded by materials normally found within the human body. This review will present the process of electrospinning and describe the use of natural polymers in the creation of bioactive ECM analogues in tissue engineering.
Subfields: Biomaterials, Surgery
View Paper: https://www.semanticscholar.org/paper/3c3a8aba8bc5d687c1114d200f4fad25047ee2a3
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In Biomaterials
Citations in the corpus
- Natural Polymeric Scaffolds in Bone Regeneration (2020, background): “…hydraulic permeability of the gel inversely correlate: it was demonstrated that in gels with higher fibril densities and low hydraulic permeability, the application of a plastic static compression greatly increases their modulus and reduces the MSC-induced gel contraction (Serpooshan et al., 2010).”
- Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications. (2016, background): “Natural polymers such as collagen, chitosan, stearic acid and serum albumin have been studied as coatings on the surface of Mg and its alloys for anti-corrosive as well as biocompatible properties [100, 101].”
- Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives (2016, background): “Collagen type II is composed of three identical α1(II) chains and form fibrils less than 80 nm in diameter [21].”