Morphologic Reappraisal of Serrated Colorectal Polyps

By E. Torlakovic, E. Skovlund, D. Snover, G. Torlakovic, J. Nesland. American Journal of Surgical Pathology, 2003

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Colorectal carcinoma: Pathologic aspects. (2012, background): “HPs can be further divided into microvesicular, goblet cell and mucin-poor subtypes (43), but this histologic subclassification does not appear to have any clinical relevance.”
BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum (2004, background): “…3 the fact that sessile serrated adenomas occur frequently not only in hyperplastic polyposis 12 but also sporadically in the proximal colon, 11 13 and finally the fact that there are no data indicating biological differences between SSA that occur sporadically or in the context of…”
Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel (2012, methodology): “The rationale for the terminology in Table 1 has been described previously (11, 21).”
Update on the serrated pathway to colorectal carcinoma. (2011, background): “As recently as 2003, all of the various serrated lesions were considered hyperplastic or “metaplastic” polyps, and their malignant potential was not well recognized, but it is now generally recognized that these lesions represent a complex family of lesions differing in their specific underlying mut”