Update on the serrated pathway to colorectal carcinoma.

By D. Snover. Human Pathology, 2011

652 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features. (2014, background): “This makes the development of new molecular modalities of classification of CRC a complex task [2].”
Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline (2017, background): “Sessile serrated adenomas/polyps are more likely to be located in the right colon (75%), accounting for approximately 5%–25% of all serrated lesions [213, 216].”
Deep Learning for Classification of Colorectal Polyps on Whole-slide Images (2017, background): “However, in a recent colorectal cancer study, more than 7,000 patients underwent colonoscopy in 32 centers—ultimately, a sessile serrated polyp was not diagnosed in multiple centers despite the statistical unlikeliness of this outcome [41].”
Colorectal carcinoma: Pathologic aspects. (2012, background): “Colorectal cancers with CpG island methylator phenotype (CIMP) are characterized by epigenetic loss of function of tumor suppressor genes without mutations (49,113).”