BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum

By T. Kambara, L. Simms, V. Whitehall, K. Spring, C. Wynter, M. Walsh, M. Barker, S. Arnold, A. McGivern, N. Matsubara and 5 more. Gut, 2004

764 citations recorded by the source corpus.

Subfields: Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/52275223b8a0b5370bf54a0aa43e51d3700b267f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. Edward L. Giovannucci
2. Peter W. Laird
3. Douglas Rex

In Pathology and Forensic Medicine

1. Edward L. Giovannucci
2. Peter W. Laird
3. Douglas Rex

Citations in the corpus

• ACG Clinical Guidelines: Colorectal Cancer Screening 2021. (2021, background): “, CpG island methylator phenotype), and a presumed more rapid progression to CRC; these lesions are also more prevalent in the proximal colon, a location where we recognize colonoscopy to be less protective for CRC compared with the distal colon (150,184,185).”
• Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers. (2005, background): “There has recently been a great deal of speculation that microsatellite-unstable colorectal cancers may develop from a subset of hyperplastic polyps (which often have BRAF mutations and are CIMP high) rather than from traditional adenomas (8).”
• CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer (2006, background): “The odds ratio for this association is 203 (95% confidence interval (CI), 41–995), a far stronger association of CIMP and BRAF mutation than any reported so far in the literatur”
• CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer (2008, background): “[7,8] CIMP-high colon cancers have been associated with older age, cigarette smoking, proximal tumor location, female gender, poor differentiation, BRAF mutation, wild-type TP53, inactive β-catenin/WNT and stable chromosomes,[8–19] and many of these associations are independent of MSI status.”
• CpG island methylator phenotype in cancer (2004, neutral): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=673"> BRAF”
• Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN and FOCUS studies (2014, background): “(32, 33) The strong interrelationship between BRAFMT and dMMR is well established in early stage CRC(14, 34), however the etiology of both alterations still needs to be elucidated.”