VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
By D. Lambrechts, E. Storkebaum, M. Morimoto, J. Del-Favero, F. Desmet, S. Marklund, S. Wyns, V. Thijs, Jörgen Andersson, I. V. Marion and 24 more. Nature Genetics, 2003
904 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/b5360246d324f6eb15d923e2d68146c25e80aa90
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In Genetics
In Molecular Biology
In Neurology
- Berislav Zlokovic
- Jeffrey D. Rothstein
- C. Iadecola
- Mark P. Mattson
- R. Bell
- M. Sofroniew
- A. Sagare
- R. Daneman
Citations in the corpus
- Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. (2007, positive): “Conversely, low VEGF-A levels have been linked to motor neuron degeneration in both animal models and human disease.(6,7) Taken together, these results suggest an important role for VEGF-A in neuronal development and maintenance within the central nervous system.”
- The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease (2005, background): “As recent work on ALS demonstrates [48,49], it is likely that new insights into the importance of VEGFs for disease will continue to be generated.”
- Current hypotheses for the underlying biology of amyotrophic lateral sclerosis (2009, background): “Clinical trials of VEGF are anticipated because three single nucleotide polymorphisms in the VEGF gene were identified as significant risk factors for ALS in a large European patient cohort.(41)”
- The blood-brain barrier in health and chronic neurodegenerative disorders. (2008, positive): “Recent in vitro and in vivo data show that VE-cadherin is required for endothelial integrity in quiescent vessels and for the correct organization of new vessels (Lampugnani and Dejana, 2007).”