The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease
By D. Holmes, I. Zachary. Genome Biology, 2005
609 citations recorded by the source corpus.
SummaryVascular endothelial growth factors (VEGFs) are a family of secreted polypeptides with a highly conserved receptor-binding cystine-knot structure similar to that of the platelet-derived growth factors. VEGF-A, the founding member of the family, is highly conserved between animals as evolutionarily distant as fish and mammals. In vertebrates, VEGFs act through a family of cognate receptor kinases in endothelial cells to stimulate blood-vessel formation. VEGF-A has important roles in mammalian vascular development and in diseases involving abnormal growth of blood vessels; other VEGFs are also involved in the development of lymphatic vessels and disease-related angiogenesis. Invertebrate homologs of VEGFs and VEGF receptors have been identified in fly, nematode and jellyfish, where they function in developmental cell migration and neurogenesis. The existence of VEGF-like molecules and their receptors in simple invertebrates without a vascular system indicates that this family of growth factors emerged at a very early stage in the evolution of multicellular organisms to mediate primordial developmental functions.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/f1fcf557f342a5bd22a7e81e66238700c17d9054
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Citations in the corpus
- Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis. (2018, background): “Orf virus is a parapoxvirus causing infections in goats and sheep, which may be transmitted to humans, producing skin lesions of pustulous dermatitis type [24, 83], characterized by local edema, vasodilatation, keratinocytes and endothelial cells proliferation, as well as abundant inflammatory infil”
- Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways (2006, neutral): “, 1989 ; Holmes and Zachary , 2005 ) .”