Using competitive exclusion, mannan-oligosaccharide and other intestinal products to control necrotic enteritis

By C. Hofacre, T. Beacorn, S. Collett, G. Mathis. 2003

154 citations recorded by the source corpus.

Abstract Clinical and subclinical necrotic enteritis (NE) caused by the ubiquitous bacteria Clostridium perfringens can have a significant economic impact in broiler chickens. This impact is especially apparent when antibiotic feed additives are not used. In this study, the effectiveness of five nonantibiotic feed additives and two competitive exclusion (CE) cultures were compared using an NE challenge model. Untreated male broiler chickens housed in an environmentally controlled facility were challenged with C. perfringens and had high mortality, gross intestinal lesions, poor feed utilization, and reduced body weights. Broilers treated with a defined lactic acid bacterial CE culture at 1 d and fed a diet containing 2 g/ton of mannan-oligosaccharide had the lowest mortality from necrotic enteritis. The feed efficiency of this combined treatment was similar to that of broilers fed a diet containing 50 g/ton of bacitracin methylene disalicylate. The treatment in which broilers were given an undefined CE or the mannan-oligosaccharide alone, as well as three other feed additives, did not have any significant effect on feed efficiency, mortality, or body weight over the NE challenge control birds. The findings of this study are very important in developing nutritional strategies to provide options for prevention of NE without continuously using antibiotics in feed.

Subfields: Animal Science and Zoology, Infectious Diseases, Small Animals

View Paper: https://www.semanticscholar.org/paper/b52ff2a658fc8e22e754f082618db2e6e64df0cd

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In Animal Science and Zoology

1. J. Dahiya
2. F. Immerseel
3. M. Drew
4. F. Gaggía
5. D. Wilkie
6. B. Biavati
7. A. V. Kessel

Citations in the corpus

• Effect of a dietary essential oil mixture on performance of laying hens in the summer season (2006, unknown): “The effects of MOS on broiler performance were studied by Santin et al. (2001), Hofacre et al. (2003) and Waldroup et al. (2003).”
• Probiotics and prebiotics in animal feeding for safe food production. (2010, background): “Lactobacilli were also successful in decreasing mortality due to necrotic enteritis from 60% to 30% in a challenge trial, when they were given orally at day 1 of life (Hofacre et al., 2003).”
• Potential strategies for controlling necrotic enteritis in broiler chickens in post-antibiotic era (2006, background): “Mortality due to necrotic enteritis was significantly reduced from 60 to 30% in an experimentally challenged broilers when they were treated with a defined lactic acid bacterial culture at day 1 of age (Hofacre et al., 2003).”
• Clostridium perfringens in poultry: an emerging threat for animal and public health (2004, background): “Lactobacilli were successful in decreasing mortality due to necrotic enteritis from 60% to 30% in an experimental challenge trial, when they were given orally at day 1 of life (Hofacre et al. , 2003).”