Metabonomics: a platform for studying drug toxicity and gene function

By Jeremy K. Nicholson, J. Connelly, John C. Lindon, Edward C. Holmes. Nature reviews. Drug discovery, 2002

1,840 citations recorded by the source corpus.

Subfields: Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/b43d451f81a0f5b322683fa3caf29e1f9464c0db

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Citations in the corpus

Correlative GC-TOF-MS-based metabolite profiling and LC-MS-based protein profiling reveal time-related systemic regulation of metabolite–protein networks and improve pattern recognition for multiple biomarker selection (2005, methodology): “Metabolite measurements have been used for decades to characterize biological systems (Gerhardt et al., 1987; Nicholson et al., 1999, 2002; Trethewey et al., 1999; Ott et al., 2003; Sumner et al., 2003; Castrillo and Oliver, 2004; Goodacre et al., 2004).”
Global metabolic profiling of animal and human tissues via UPLC-MS (2012, methodology): “Test mixture Retention time Peak shape Signal intensity Mass accuracy (1) Test mixture is injected at the start of the run to assess whether the instrumental setup is suitable for the analysis (2) Test mixture is injected at the end of the run to assess whether major changes have occurred during the”
Molecular imaging in drug discovery and development (2003, neutral): “Finally, imaging competes with alternative technologies that can provide similar decision-making information; genomic and proteomic sciences detect altered expression levels associated with disease and/or therapy response, and metabonomics potentially yields biomarkers for drug efficacy or for poten”
A new approach to toxicity testing in Daphnia magna: application of high throughput FT-ICR mass spectrometry metabolomics (2009, positive): “Although metabolomics is also recognised to be a powerful tool for investigating toxicity (Coen et al. 2008; Nicholson et al. 2002; Robosky et al. 2002), including in the field of aquatic toxicology (Ekman et al. 2008; Viant et al. 2005, 2006), no metabolomics studies of this widely utilised test ”
Gut microorganisms, mammalian metabolism and personalized health care (2005, background): “Consequently, there will be a complex fingerprint of molecular markers associated with a disease, and the efficacy or toxicity of drugs will evolve through tim”
Global metabolic profiling procedures for urine using UPLC–MS (2010, background): “Key factors to consider when designing UPLC–MS metabolite profiling experiments include (1) sample collection and storage; (2) column conditioning; (3) the composition of test mixtures used; (4) the type and number of quality control samples and any ‘blank’ samples; (5) run order, i.”
Metabolic phenotyping in health and disease. (2008, background): “…are based on spectroscopic techniques, e.g., nuclear magnetic resonance (NMR) spectroscopy or mass spectrometry (often combined with chromatographic separation), to permit extensive and rapid analysis of small molecule metabolites, generally with minimal sample preparation (Nicholson et al., 2002).”
Innovation: Metabolomics: the apogee of the omics trilogy (2012, background): “This approach can be effective for pharmacokinetic studies of drug metabolism as well as for measuring the influence of therapeutics or genetic modifications on a specific enzym”
Data mining in the Life Sciences with Random Forest: a walk in the park or lost in the jungle? (2012, neutral): “[37].”
Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, methodology): “Historically, metabolomics has been primarily used to diagnose diseases or detect pathological conditions (54, 175, 316, 350).”
Molecular imaging in living subjects: seeing fundamental biological processes in a new light. (2003, background): “…proteomics, metabolomics (which investigates metabolic regulation and fluxes in individual cells or cell types), and metabonomics (the determination of systemic biochemical profiles and regulation of function in whole organisms by analyzing biofluids and tissues; Nicholson et al. 2002).”