The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine.

By R. Burstein, M. Cutrer, D. Yarnitsky. Brain : a journal of neurology, 2000

745 citations recorded by the source corpus.

Subfields: Pathology and Forensic Medicine, Psychiatry and Mental health, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/b3e7e84804ff2c619d8cced2bb6f73f882f12e8f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pathology and Forensic Medicine

1. Clifford J. Woolf
2. R. Noseda
3. R. Burstein
4. P. Goadsby

In Psychiatry and Mental health

1. Clifford J. Woolf
2. P. Goadsby
3. R. Noseda
4. R. Burstein

In Sensory Systems

1. Clifford J. Woolf
2. P. Goadsby
3. R. Burstein

Citations in the corpus

• Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management (2004, background): “It possesses features of inflammatory and functional pain, as well as of objective neurologic dysfunction (11, 12).”
• Acute Migraine Medications and Evolution From Episodic to Chronic Migraine: A Longitudinal Population‐Based Study (2008, background): “Repetitive activation of the PAG may, in turn, lead to impairment of neuronal function at this area with further predisposition to migraine.(28,29) We also found that specific medications (barbiturates and opioids) are associated with incident TM, and now considered putative mechanisms.”
• Pathophysiology of Migraine: A Disorder of Sensory Processing. (2017, background): “Sensitization of trigeminothalamic neurons is likely to account for the widespread cutaneous allodynia to extracephalic regions (128, 132).”
• Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain (2013, background): “Peripheral sensitization mediates the throbbing perception of the headache [122] (Figure 3), whereas sensitization of second-order neurons in the SpVC mediates cephalic allodynia as well as muscle tenderness [19; 21] (Figure 4).”
• PATHOPHYSIOLOGY OF MIGRAINE (2006, background): “About two thirds of patients report pain from nonnoxious stimuli, allodynia (Burstein et al, 2000; Selby and Lance, 1960).”
• Central sensitization: Implications for the diagnosis and treatment of pain (2010, background): “These changes could include a reduction in threshold, exaggerated response to a noxious stimulus, pain after the end of a stimulus, and a spread of sensitivity to normal tissue.”