PATHOPHYSIOLOGY OF MIGRAINE

By P. Goadsby. Neurologic clinics, 2006

697 citations recorded by the source corpus.

Primary headache is a common problem in neurology. The main disabling form of primary headache presenting to neurologists is migraine, either episodic or chronic. Migraine is an inherited disorder of the brain that involves dysfunction of subcortical structures that modulate sensory input. Its therapy involves reducing afferent traffic or stabilizing these abnormal pathways. Understanding the pathophysiology of migraine is integral to providing explanations to patients and good management strategies.

Subfields: Pathology and Forensic Medicine, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/0313489c869e0d9cbb780d9006ae9bebab1a1934

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pathology and Forensic Medicine

1. G. Zamponi
2. R. Burstein
3. R. Noseda
4. Brett A. Simms

In Physiology

1. G. Zamponi
2. R. Burstein
3. R. Noseda
4. Brett A. Simms

In Psychiatry and Mental health

1. G. Zamponi
2. R. Burstein
3. R. Noseda
4. Brett A. Simms

Citations in the corpus

• Guidelines for the Primary Prevention of Stroke (2011, neutral): “These include disturbance of cortical excitability, cortical spreading depression, meningeal inflammation, and activation of the trigeminovascular system.(603) However, factors contributing to the increased risk of stroke with migraine remain elusive.”
• The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential (2015, background): “The various mutations can lead to drastic differences in disease severity consistent with the notion that FHM-1 has a wide spectrum of clinical phenotypes (Pietrobon and Moskowitz, 2013).”
• Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain (2013, background): “Because of the complexity of this disorder, which is not limited to its multifactorial origin but also includes remarkable premonitory symptomatology, it is thought that migraine headache is a manifestation of a brain state of altered excitability capable of activating the trigeminovascular system i”
• Neuronal calcium signaling: function and dysfunction (2014, background): “Migraine is a disorder of brain excitability which has complex physiopathological mechanisms [236] that have begun to be understood only recently thanks to the use of mouse models of familial hemiplegic migraine (FHM), a rare genetic autosomal-dominant form of MA.”
• Neuronal voltage-gated calcium channels: structure, function, and dysfunction. (2014, background): “, 2009), with mutation loci determining a wide range of disease severity (Pietrobon and Moskowitz, 2013).”