Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management

By Clifford J. Woolf. Annals of Internal Medicine, 2004

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Central sensitization: Implications for the diagnosis and treatment of pain (2010, background): “pathic and dysfunctional pain disorders in patients [53,258].”
Consequences of inadequate postoperative pain relief and chronic persistent postoperative pain. (2005, background): “Recent research has advanced our understanding of the role of COX-2 and prostanoids in neural plasticity and pain sensitization [69].”
The Kyoto protocol of IASP Basic Pain Terminology. (2008, background): “‘‘Inflammatory pain” (pain associated with active inflammation) falls into the category of nociceptive pain, although it is recognized that the nociceptive system may be altered in chronic inflammatory pain [14].”
What we know about primary dysmenorrhea today: a critical review. (2015, background): “Central sensitization is defined as an abnormal augmentation of pain by mechanisms within the central nervous system (CNS), and therefore represents a state where the response to normal peripheral inputs is greatly enhanced (Woolf, 2004, 2007).”