Salt-responsive gut commensal modulates TH17 axis and disease

By N. Wilck, M. Matus, Sean M. Kearney, S. Olesen, Kristoffer Forslund, H. Bartolomaeus, S. Haase, A. Mähler, A. Balogh, L. Markó and 29 more. Nature, 2017

1,140 citations recorded by the source corpus.

A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T helper 17 (TH17) cells, which can also contribute to hypertension. Induction of TH17 cells depends on gut microbiota; however, the effect of salt on the gut microbiome is unknown. Here we show that high salt intake affects the gut microbiome in mice, particularly by depleting Lactobacillus murinus. Consequently, treatment of mice with L. murinus prevented salt-induced aggravation of actively induced experimental autoimmune encephalomyelitis and salt-sensitive hypertension by modulating TH17 cells. In line with these findings, a moderate high-salt challenge in a pilot study in humans reduced intestinal survival of Lactobacillus spp., increased TH17 cells and increased blood pressure. Our results connect high salt intake to the gut–immune axis and highlight the gut microbiome as a potential therapeutic target to counteract salt-sensitive conditions.

Subfields: Biological Psychiatry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/b3bc500f559eae6bbfc62d290c204650fc35d0d9

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In Molecular Biology

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Citations in the corpus

• The Human Gut Microbiome: From Association to Modulation. (2018, neutral): “Thus, in vitro screens can 426 serve as massive hypothesis generators to guide the study of microbiome perturbation 427 responses in vivo, either in animal models, or directly in humans, as shown in a recent study on 428 the impact of salt on the microbiome (Wilck et al., 2017).”
• A practical guide to amplicon and metagenomic analysis of microbiome data (2020, methodology): “3G) (Wilck et al., 2017) or feature patterns in a time series (Subramanian et al., 2014).”