Faculty Opinions recommendation of In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.

By N. Chao. 2008

726 citations recorded by the source corpus.

Subfields: Surgery

View Paper: https://www.semanticscholar.org/paper/b3aa57a18b89a9e663ffab34d72ed954b2f26def

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In Surgery

Citations in the corpus

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors (2010, background): “…with Pdx1 and Mafa, can efficiently reprogram pancreatic exocrine cells into functional b cells in vivo, although the exocrine cells were known to have some potential to become islet cells in vitro and share a common parent cell with islet cells (Baeyens et al., 2005; Zhou et al., 2008).”
Type 1 diabetes: etiology, immunology, and therapeutic strategies. (2011, background): “This can be done by differentiation of embryonic stem (ES) cells (234) or pluripotent stem (IPS) cells (487), or the “reprogramming” of cells from their initial phenotype into beta-like cells (494).”
A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure (2016, positive): “…ESR1, and RXRG. Combinations of cell type-specific transcription factors have allowed reprogramming between pancreatic lineages (Li et al., 2014; Zhou et al., 2008), and the role of these transcriptional regulators in development and the maintenance of cell type identity merit further…”
Control of Embryonic Stem Cell State (2011, background): “PcG proteins are thought to inhibit transcription, at least in part, by restraining poised RNA polymerase molecules (Stock et al., 2007; Zhou et al., 2008b).”
Super-enhancers in the control of cell identity and disease. (2013, positive): “…regulatory circuitry of cells, and to facilitate efforts to reprogram cells for regenerative medicine, it would be valuable to identify the master transcription factors that control all cell states (Cherry and Daley, 2012; Graf and Enver, 2009; Lee and Young, 2013; Zhou et al., 2008).”
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. (2011, neutral): “Such differentiation-state plasticity occurs in response to either genetic or microenvironmental perturbations (Deng et al., 2011; Thorel et al., 2010; Zhou et al., 2008) and has also been observed during normal developmental processes (Richard et al.”
Induced pluripotent stem cells: past, present, and future. (2012, neutral): “Melton and colleagues reported the conversion of exocrine cells to endocrine cells in the mouse pancreas by using a combination of three transcription factors (Zhou et al., 2008).”
Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, neutral): “…[1] Weintraub et al., 1989; [2] Xie et al., 2004; [3] Ieda et al., 2010; [4] Tachibana et al., 1996; [5] Vierbuchen et al., 2010; [6] Cobaleda et al., 2007; [7] Zhou et al., 2008; [8] Uhlenhaut et al., 2009. resultant cells retained expression of fibroblast markers and had reduced expression…”
Pluripotency: Toward a gold standard for human ES and iPS cells (2009, background): “In a recent study, Zhou et al. (2008) successfully reprogrammed adult pancreatic exocrine cells in adult mice to functional b-cells by re-expressing three factors (Ngn3, Pdx1 and Mafa).”
Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling (2011, positive): “Transcription factors bind specific DNA sequences and regulate gene expression (Ptashne, 1988), and master transcription factors are required for establishment, maintenance, and even reprogramming of cell identity (Takahashi and Yamanaka, 2006; Feng et al., 2008; Lassar et al., 1986; Seale et al., 2”
Transcriptional Regulation and its Misregulation in Disease (2013, neutral): “…expressed in various cell types (Buganim et al., 2012; Davis et al., 1987; Huang et al., 2011; Ieda et al., 2010; Kajimura et al., 2009; Marro et al., 2011; Pang et al., 2011; Sekiya and Suzuki, 2011; Takahashi and Yamanaka, 2006; Vierbuchen et al., 2010; Xie et al., 2004; Zhou et al., 2008).”