Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation

By B. Keselowsky, D. Collard, Andrés J. García. Proceedings of the National Academy of Sciences of the United States of America, 2005

674 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Surfaces, Coatings and Films

View Paper: https://www.semanticscholar.org/paper/b3a1526de414b812a93c3ec325e8e82cd513277b

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In Cell Biology

In Immunology and Allergy

In Surfaces, Coatings and Films

Citations in the corpus

Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair (2015, background): “Cells that were cultured on fibronectin adsorbed onto OH and NH2 surfaces had significantly more ALP expression andmineralization compared to COOHandCH3 surfaces [52].”
Harnessing Traction-Mediated Manipulation of the Cell-Matrix Interface to Control Stem Cell Fate (2010, result): “These results are consistent with previous work highlighting roles for both α 5 - and α V -integrin ligation in osteogenesi”
Cell Responses to Surface and Architecture of Tissue Engineering Scaffolds (2011, background): “Same group also demonstrated that surfaces grafted with hydroxyl and amine groups up-regulated osteoblast-specific gene expression, alkaline phosphatase enzymatic activity, and matrix mineralization compared with surfaces presenting carboxyl and alkyl groups (Keselowsky et al., 2005).”
Foreign body reaction to biomaterials. (2008, background): “Surfaces with varying properties promote differential cellular integrin binding to the absorbed protein layer[43–46] Subsequent material dependent differences in cell adhesion and cytoskeletal rearrangement correlate to differences in phosphorylation of FAK and ERK[47, 48] and differences in recruit”
Local force and geometry sensing regulate cell functions (2006, background): “For a synthetic surface, however, it is not just the geometry and rigidity but also its surface chemistry that ultimately controls the composition and conformation of surface-adsorbed proteins and, therefore, the integrin-mediated cell-signalling processe”
Mammalian Cell Behavior on Hydrophobic Substrates: Influence of Surface Properties (2019, background): “Reports in the literature demonstrated the control of cell adhesion of MC3T3 osteoblasts on surfaces functionalized with ionizable groups by modulation of fibronectin adsorption and integrin binding, following the trend OH > COOH = NH2 > CH3 [55].”