The enteric nervous system and neurogastroenterology

By John B. Furness. Nature Reviews Gastroenterology &Hepatology, 2012

1,397 citations recorded by the source corpus.

Neurogastroenterology is defined as neurology of the gastrointestinal tract, liver, gallbladder and pancreas and encompasses control of digestion through the enteric nervous system (ENS), the central nervous system (CNS) and integrative centers in sympathetic ganglia. This Review provides a broad overview of the field of neurogastroenterology, with a focus on the roles of the ENS in the control of the musculature of the gastrointestinal tract and transmucosal fluid movement. Digestion is controlled through the integration of multiple signals from the ENS and CNS; neural signals also pass between distinct gut regions to coordinate digestive activity. Moreover, neural and endocrine control of digestion is closely coordinated. Interestingly, the extent to which the ENS or CNS controls digestion differs considerably along the digestive tract. The importance of the ENS is emphasized by the life-threatening effects of certain ENS neuropathies, including Hirschsprung disease and Chagas disease. Other ENS disorders, such as esophageal achalasia and gastroparesis, cause varying degrees of dysfunction. The neurons in enteric reflex pathways use a wide range of chemical messengers that signal through an even wider range of receptors. These receptors provide many actual and potential targets for modifying digestive function.

Subfields: Gastroenterology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/b39147404dc9e3838a17a92bf85097109ac2600b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Gastroenterology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. T. Kam
6. H. Ko
7. Sangjune Kim
8. Nikhil Panicker

In Psychiatry and Mental health

1. T. Kam
2. H. Ko
3. Sangjune Kim
4. Nikhil Panicker
5. Seung-Hwan Kwon

Citations in the corpus

• Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease. (2019, methodology): “5 mg/mL) was injected in two different locations in the pylorus and two different locations in the duodenum between the longitudinal and intermediate muscle layers where the myenteric plexus resides (Figure 1A; Furness, 2012).”
• Kynurenine pathway metabolism and the microbiota‐gut‐brain axis (2017, background): “A complex reflexive network of efferent and afferent fibers between the gastrointestinal (GI) tract and the CNS facilitate interactions within the axis (Furness, 2012).”