Oxidative stress in neurodegeneration: cause or consequence?

By J. Andersen. Nature Reviews Neuroscience, 2004

1,886 citations recorded by the source corpus.

Subfields: Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/b33b8c0eed78ad239a703d253e5638e78e54ca9b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. A. Abramov
2. S. Gandhi
3. M. Duchen
4. Michael Lawson
5. M. Valko
6. Michael R Hamblin
7. D. Vondrakova
8. G. Tezel

In Physiology

1. M. Duchen
2. A. Abramov
3. S. Gandhi
4. Michael Lawson
5. Chunyan Guo
6. Li Sun
7. Xueping Chen
8. M. Valko

Citations in the corpus

• Transcriptional paradigms in mammalian mitochondrial biogenesis and function. (2008, background): “Although there is good evidence for oxidative stress associated with neuropathology, it has been difficult to prove whether this is a cause or a consequence of neuronal death (5).”
• Oxidative stress, mitochondrial damage and neurodegenerative diseases (2013, background): “Oxidative changes to proteins such as β-amyloid in AD may result in protein misfolding and aggregate formation [51] .”
• Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies (2017, background): “Once excessive ROS are generated in the gut, oxidative stress can accelerate cell damages by modifying the functions of proteins and causing lipid peroxidation [109].”
• The Role of Oxidative Stress in Parkinson’s Disease (2013, neutral): “to neuronal degeneration [19, 20].”
• PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death (2009, background): “Oxidative stress has long been implicated in sporadic PD: there is evidence of elevated levels of lipid peroxidation markers (4-hydroxynonenal and malondialdehyde) and protein nitration in the substantia nigra and in Lewy bodies of patients with PD (Andersen, 2004).”
• Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. (2006, background): “Consequently, oxidative damage has been implicated in a wide variety of neurodegenerative diseases, as well as degenerative processes of aging (Andersen, 2004; Potashkin and Meredith, 2006).”
• Thioredoxin and Related Molecules–From Biology to Health and Disease (2007, neutral): “MOLECULES IN TISSUES A. Reproduction and development none of the established electron donors for RNR, Trx1 or Grx1, co-localizes with the enzyme in rat and calf testes, where RNR is primary localized in spermatogonia (65, 200).”
• Hallmarks of neurodegenerative diseases. (2023, neutral): “185,187 Persistent alterations in DNA can drive adverse molecular events, such as mutagenesis, chromosome rearrangements, RNA transcription arrest, or DNA replication fork collapse, events that can promote cell dysfunction and cell death.”