Thioredoxin and Related Molecules–From Biology to Health and Disease

By C. Lillig, A. Holmgren. Antioxidants and Redox Signaling, 2007

715 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/11074257e2ca5b637cfb9c43d563fd06b03d214e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. C. Winterbourn
2. P. Nagy
3. D. Gupta
4. J. Palma
5. PA Marks
6. Dean P. Jones
7. F. J. Corpas
8. H. Sies

In Molecular Biology

1. P. Nagy
2. PA Marks
3. Weisheng Xu
4. R. Parmigiani
5. C. Winterbourn
6. D. Gupta
7. Qitao Ran
8. J. Palma

Citations in the corpus

• Is the Oxidative Stress Theory of Aging Dead? (2009, background): “), but also plays a major role in repairing the oxidation of cysteine residues in proteins [47].”
• Redox chemistry of biological thiols (2010, background): “These enzymes themselves function via reversible inter- and intramolecular thiol–disulfide (or seleno–sulfide) cycles [134–137].”
• Radical-free biology of oxidative stress. (2008, background): “Kinetic studies with different proteins, however, show that there is an underlying specificity for target proteins in terms of the rates of catalysis (14, 74, 110).”
• Histone deacetylase inhibitors: molecular mechanisms of action (2007, background): “Thioredoxin (Trx) acts as a hydrogen donor required for activation of many proteins, including ribonucleotide reductase that is essential for DNA synthesis, and transcription factors, for example, nuclear factor kB (NF-kB), and is an antioxidant scavenger of ROS (Lillig and Holmgren, 2007).”
• Antioxidants and Antioxidant Enzymes in Higher Plants (2018, background): “…with an additional antioxidant system, compared with yeast, which presents three isoforms, Escherichia coli with two Trxs, or mammals where only two types of Trx have been described: Trx1 and Trx2, in the cytosol and mitochondria, respectively (Schürmann and Jacquot 2000; Lillig and Holmgren 2007).”
• Redox Regulation of Cell Survival (2008, neutral): “Although many ROS are quenched by GSH through reaction with its thiol group, other thiol-containing proteins are also attacked by ROS, leading to their oxidation (184).”
• Selenium in Human Health and Disease (2011, neutral): “Trx can bind to apoptosis signal regulating kinase 1 (ASK1) and modulates apoptosis (223, 258, 315).”