Parental olfactory experience influences behavior and neural structure in subsequent generations
By B. Dias, K. Ressler. Nature Neuroscience, 2013
1,153 citations recorded by the source corpus.
Using olfactory molecular specificity, we examined the inheritance of parental traumatic exposure, a phenomenon that has been frequently observed, but not understood. We subjected F0 mice to odor fear conditioning before conception and found that subsequently conceived F1 and F2 generations had an increased behavioral sensitivity to the F0-conditioned odor, but not to other odors. When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an enhanced neuroanatomical representation of the Olfr151 pathway. Bisulfite sequencing of sperm DNA from conditioned F0 males and F1 naive offspring revealed CpG hypomethylation in the Olfr151 gene. In addition, in vitro fertilization, F2 inheritance and cross-fostering revealed that these transgenerational effects are inherited via parental gametes. Our findings provide a framework for addressing how environmental information may be inherited transgenerationally at behavioral, neuroanatomical and epigenetic levels.
Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Sensory Systems
View Paper: https://www.semanticscholar.org/paper/b2f0457b948399f7653b03e0f460ef2a4f29b05a
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In Cellular and Molecular Neuroscience
In Sensory Systems
Citations in the corpus
- Slow-Wave Sleep-Imposed Replay Modulates Both Strength and Precision of Memory (2014, background): “…paradigms using natural odors generally involve 10 –20 s CS presentations during training and 20 s or longer CS presentations during testing to assess freezing (Funk and Amir, 2000; Hegoburu et al., 2009; Pavesi et al., 2012; Kass et al., 2013; Roth et al., 2013; Dias and Ressler, 2014).”
- DNA methylation on N6-adenine in C. elegans (2015, neutral): “…including physical appearance (Cavalli and Paro, 1998; Morgan et al., 1999), energy metabolism (Benyshek et al., 2006), behavioral state (Dias and Ressler, 2014), and longevity (Greer et al., 2011; Rechavi et al., 2014), have been shown to be regulated in part by non-genetic information.”
- Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress (2015, background): “In particular, the role of sperm RNA as a mechanistic link between paternal experience and its consequences on offspring behavior and physiology has been emphasized by recent studies that characterize offspring phenotypes following in vitro fertilization and/or the experimental manipulation of total”