HUMAN DISEASE

By H. Waller. 1957

DR. CLARK-KENNEDY, physician to the London Hospital and Dean of the Medical School, and well known for his original presentation of medicine in the several textbooks he has written, has now produced a book for the layman. Many will still think that for the population generally, and especially for the more neurotic section of it likely to be most interested in this type of book, a little knowledge is a dangerous thing. The author ranges widely, and on the whole wisely, over a wide variety of topics. Extreme compression can easily lead to misunderstanding and the expression of half-truths, but the author probably manages to avoid this better than most books of this kind. The book should be useful to students of the social sciences and medical students will find it stimulating in parts and of some general interest. THIS small volume represents the teaching of the late Dr. Harold Waller. As all those interested in the feeding of the newborn are aware, Dr. Waller attained an outstanding place in presenting his views on the feeding of infants by natural methods. Obstetricians and pediatricians owe a debt of gratitude to him for his great contribution to this important field. Obstetricians and paediatricians will appreciate the quality of his teaching, and midwives too will be glad to have his advice presented in this attractive book. It is concise, well written, and more. than adequately illustrated. THIS is a book which concerns every parent, though it is especially important for teachers and all those who handle children. A concise account is given of a child's behaviour from infancy to adolesence. The difficulties which may arise at various stages and the methods of treating them are described. The book is illustrated by case histories and photographs, and there is an extensive bibliography at the end of each chapter. THIS annual volume is now well known to many general practitioners. This year there are thirty-two articles by experts in various branches of medicine and surgery dealing with the treatment of such conditions as coronary thrombosis, disturbed nights in the elderly, gangrene of the extremities, tumours of the bladder, the management of colostomies and of incurable malignant disease. The articles are uniformly good and, although concerned primarily with treatment, they impart much information on symptomatology and diagnosis. The general style of the annual has always been attractive, making for easy reading. In the present volume …

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Citations in the corpus

EgoNet: identification of human disease ego-network modules (2014, background): “In contrast to studying individual genes in isolation, mapping human disease-associated genes to interactome data has greatly empowered our understanding of human disease mechanisms [9].”
Uncovering disease-disease relationships through the incomplete human interactome (2015, background): “This agglomeration of disease proteins is supported by a range of biological and empirical evidence (7, 17, 18) and has fueled the development of numerous tools to identify new disease genes and prioritize pathways for disease relevance (8, 9, 19–28).”
Systems Pharmacology: Network Analysis to Identify Multiscale Mechanisms of Drug Action (2012, background): “Edges can also be defined on the basis of similarities between two nodes such as the chemical or therapeutic similarity (6), the similarities between proteins based on the shared number of diseases (14), or the similarities of diseases based on the shared number of genes (14).”
The implications of human metabolic network topology for disease comorbidity (2008, background): “Previous work has indicated that although most diseases can be grouped into a human disease network based on the genes the diseases share, metabolic diseases are the most disconnected class in this network (18).”
Three-dimensional reconstruction of protein networks provides insight into human genetic disease (2012, background): “Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex.”
Learning on Weighted Hypergraphs to Integrate Protein Interactions and Gene Expressions for Cancer Outcome Prediction (2008, unknown): “ilar biological functions and may lead to same or similar diseases [12, 8].”
ChemProt: a disease chemical biology database (2010, background): “Recent advances include a protein–protein association network based on the chemical toxicology of environmental chemicals (20) and a human disease network linking disorders and disease genes to various known phenotypes (21).”
Genic Intolerance to Functional Variation and the Interpretation of Personal Genomes (2013, unknown): “2007 as part of the human disease network diseasome mapping effort [26].”
The Human Phenotype Ontology: a tool for annotating and analyzing human hereditary disease. (2008, methodology): “It is also apparent that some of the clusters show interconnections between one another, which were not visible in the disease map based only on shared disease genes.(7) For instance, hematological disorders are strongly connected to immunological disorders, bone disorders are strongly connected to ”
Network-based methods for human disease gene prediction. (2011, methodology): “hubs and were widely expressed, while nonessential disease genes did not demonstrate these characteristics [8, 9].”
Hypergraphs and Cellular Networks (2009, unknown): “human–disease network [41], consisting of”
Studying protein^protein interaction networks: a systems view on diseases (2012, background): “[65] make a clear difference between essential and disease genes.”
A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases (2019, background): “Many independent studies agree that disease-associated proteins tend to cluster on the network of protein-protein interactions [43], [44], [45] (PPI).”