Ferroptosis: process and function

By Yangchun Xie, W. Hou, Xinxin Song, Yan Yu, Jin Huang, Xiaofang Sun, R. Kang, Daolin Tang. Cell Death and Differentiation, 2016

3,248 citations recorded by the source corpus.

Subfields: Cancer Research, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/b22d9cd4a3b5d90357bb935602fda16eef77f4cf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. D. Tang
2. R. Kang
3. Guido Kroemer
4. Brent R. Stockwell
5. M. Conrad
6. Tal Hirschhorn
7. D. Pratt
8. Ron Shah

In Oncology

1. D. Tang
2. R. Kang
3. Guido Kroemer
4. M. Conrad
5. Tal Hirschhorn
6. Xiaofang Sun
7. Brent R. Stockwell
8. D. Klionsky

In Pulmonary and Respiratory Medicine

1. D. Tang
2. R. Kang
3. Brent R. Stockwell
4. Guido Kroemer
5. Tal Hirschhorn
6. M. Conrad
7. Jiao Liu
8. D. Klionsky

Citations in the corpus

• The Development of the Concept of Ferroptosis (2018, positive): “[152,153] can protect cells from ferroptotic death by upregulating system Xc [132,154], and was found to be commonly overactivated in various cancers [155,156].”
• Copper homeostasis and cuproptosis in health and disease (2022, background): “Ferroptosis, an iron-dependent form of cell death, is one such example in which excess iron triggers the accumulation of lipid peroxides in membranes, leading to programmed cell death.(232,233) In addition to pathways involved in iron metabolism, several other molecular pathways have also been impli”
• Identification of ACSL4 as a biomarker and contributor of ferroptosis. (2016, background): “Althoughmultiple regulators have recently been recognized to regulate erastin-induced ferroptosis in different experimental models [14], the essential regulator of lipid metabolism in ferroptotic cancer death remains poorly defined.”
• Mitochondria ROS and mitophagy in acute kidney injury (2022, background): “Erastin, a special ferroptosis inducer, targets cystine/glutamate antiporter SLC7A11/xCT (solute carrier family 7 member 11), to inhibit extracellular cystine and intracellular glutamate exchange [120].”
• Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration (2017, background): “Although no specific markers of ferroptosis have been identified, several features in combination separate ferroptotic cell death from apoptotic cell death [25].”
• Ferroptosis, a new form of cell death, and its relationships with tumourous diseases (2016, background): “published a relatively detailed summary of ferroptosis inducers, inhibitors and regulatory molecules [18].”