Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms.

By R. Pyo, Jason K. Lee, J. Shipley, J. Curci, D. Mao, Scott J. Ziporin, T. Ennis, S. Shapiro, R. Senior, R. Thompson. Journal of Clinical Investigation, 2000

845 citations recorded by the source corpus.

Subfields: Cancer Research, Pulmonary and Respiratory Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/b21b38379ff989f3e110154bd30cf49bce1635f1

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Citations in the corpus

How matrix metalloproteinases regulate cell behavior. (2001, background): “In mice, the development of experimental aortic aneurysms is suppressed by the administration of a nonselective MMP inhibitor and by targeted disruption of the MMP9 gene, but not by selective disruption of the MMP12 gene (Pyo et al. 2000).”
Gelatinase B functions as regulator and effector in leukocyte biology (2001, background): “Prolonged, delayed hypersensitivity [42] Serpin cleavage [43] Angiogenic shift [44] Resistance to development of abdominal aortic aneurysm [ 45 ]”
Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. (2008, background): “Abdominal Aortic Aneurysm (AAA) AAA is a focal dilation of the aorta that is commonly observed in elderly individuals.”
Metalloproteinase inhibitors: biological actions and therapeutic opportunities (2002, neutral): “These include atherosclerosis (George, 1998), myocardial infarction and heart failure (Creemers et al., 2001), development and rupture of aneurysms (Pyo et al., 2000), restenosis following balloon angioplasty (Bendeck et al., 1994; Zempo et al., 1994) and the failure of vein grafts following…”
Biochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9) (2002, background): “The critical role of gelatinase B in a mouse model of aortic aneurysm disease was proven by bone marrow transplantation experiments from wild-type to gelatinase B-deficient mice and vice versa (Pyo et al., 2000).”
Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. (2005, background): “Data that MMP-9 knockout reduces neointima formation after mouse carotid artery injury (56, 86) but also protects against aneurysm formation in other mouse models (166, 217) fit with this hypothesis.”
Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. (2018, background): “MMP-2 and MMP-9 appear to be necessary to induce AAA formation in mice (Longo et al., 2002), and targeted gene disruption of MMP-9 in mice suppresses the development of AAA (Pyo et al., 2000).”