Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarrays

By J. Bernstein, Arkady B. Khodursky, Pei-Hsun Lin, S. Lin-Chao, Stanley N Cohen. Proceedings of the National Academy of Sciences of the United States of America, 2002

927 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b20b5a3f7e60a3c0929d81baa35073f4247c38f3

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Citations in the corpus

Negative autoregulation speeds the response times of transcription networks. (2002, background): “For example, mRNA lifetime in prokaryotes is usually on the order of a few minutes, while protein dilution and degradation rates are generally on the order of tens of minutes to many hours.(12,13) Indeed, numerical solutions of the system of equations obtained by explicitly calculating the mRNA leve”
Growth-rate dependent global effects on gene expression in bacteria (2009, background): “Furthermore, a genome-wide study (Bernstein et al., 2002) found that the lifetimes of most transcripts differed by less than 2-fold between growth in minimal and rich medium, with no obvious correlation between the two conditions.”
The Inferelator: an algorithm for learning parsimonious regulatory networks from systems-biology data sets de novo (2006, methodology): “If available, results from independent experiments can be used to estimate by τ [50], thus reducing the number of free paramaters in the model.”
Identifying global regulators in transcriptional regulatory networks in bacteria. (2003, background): “In fact, transcriptional interactions defines a subset of a larger network regulation including translation, RNA antisense [56], mRNA half-life [57,58 ], transcription attenuation [59] and so forth.”
Solving the riddle of codon usage preferences: a test for translational selection. (2004, methodology): “coli microarray data (33) to obtain an appropriate s-value for the recognition of AUA by LAT in prokaryotic genomes (Table 2).”
Real-time kinetics of gene activity in individual bacteria. (2005, background): “For most mRNAs, elimination is dominated by degradation (Bernstein et al., 2002), while elimination through cell growth and division has a marginal effect.”
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages (2003, background): “Because the half-lives of most bacterial transcripts are 8 min (20), these MTB expression profiles must represent de novo transcription in response to specific intracellular cues.”