Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

By Peng Zheng, B. Zeng, Chanjuan Zhou, M. Liu, Z. Fang, X. Xu, L. Zeng, Jianjun Chen, S. Fan, X. Du and 9 more. Molecular Psychiatry, 2016

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The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “MDD patients exhibit significant changes in the relative abundance of Firmicutes, Actinobacteria, and Bacteroidetes compared to healthy individuals (Zheng et al., 2016; for review, see Cheung et al., 2019).”
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019, background): “For example, transplant of microbiota from patients with depression, irritable bowel syndrome-associated anxiety, or schizophrenia into wild type mice promoted indica-tion-speciﬁc behavioral symptoms (De Palma et al., 2017; Zheng et al., 2016, 2019).”
Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018, background): “Differences in the composition of the gut microbiota in patients with depression compared with healthy individuals have been demonstrated (134).”
Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024, background): “…pathophysiology of MDD. 301 Because the interaction of bacteria of some taxa in the gut with peripheral in ﬂ ammation with the brain may be related to depression pathophysiology, 302,303 regulating the gut-microbe-brain axis may be a therapeutic and preventive strategy for psychiatric disorders.”