A genomic perspective on membrane compartment organization

By J. Bock, H. Matern, A. Peden, R. Scheller. Nature, 2001

724 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b1fc193de1e59872c381754ee542826d695cfac5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. W. Hong
2. R. Jahn
3. R. Scheller
4. A. Morgan
5. R. Burgoyne
6. S. Seino
7. Marino Zerial
8. T. Shibasaki

In Molecular Biology

1. W. Hong
2. R. Jahn
3. R. Scheller
4. A. Morgan
5. R. Burgoyne
6. S. Seino
7. Jochen S. Hub
8. Thomas Girke

Citations in the corpus

• Membrane dynamics and the biogenesis of lysosomes (Review) (2003, neutral): “complex (Bock et al. 2001).”
• The Rab GTPase family (2001, neutral): “See [3,4,39] for references and further details.”
• PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. (2005, background): “In the human, there are at least 60 Rab isoforms (45, 422, 614).”
• Rab conversion as a mechanism of progression from early to late endosomes. (2005, background): “Both SNAREs and Rab GTPases occur as large families in eukaryotic genomes (Bock et al., 2001), are enriched in specific membrane compartments, and participate in virtually every membrane trafficking reaction (Sollner et al.”
• SNAREs — engines for membrane fusion (2006, background): “Accordingly, the contributing SNARE motifs are classified into Qa-, Qb-, Qc- and R-SNARE”
• Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote (2006, neutral): “thermophila, with 69 Rabs (Table S15), has a number more along the lines of humans (which have 60) than many single-celled species, such as Saccharomyces cerevisiae, which has 11 [154] and Trypanosoma brucei, which has 16 [155].”
• The Vegetative Vacuole Proteome of Arabidopsis thaliana Reveals Predicted and Unexpected Proteinsw⃞ (2004, background): “The primary control ofmembrane fusion in eukaryotes is mediated by soluble N-ethylmaleimide–sensitive factor attach- ment protein receptor (SNARE) proteins (reviewed in Bock et al., 2001).”
• Secretory granule exocytosis. (2003, background): “Searching for similar motifs in the human genome reveals 35 SNAREs, compared with 22 in the yeast genome (84, 588).”
• Lysosomes: fusion and function (2007, background): “These residues are termed R-SNARE and Qa-, Qb- and Qc- SNAREs, respectivel”
• SNAREs and traffic. (2005, background): “Members of the VAMP subfamily are all R-SNAREs [7,8,17,28].”
• Molecular anatomy of a trafficking organelle. (2006, background): “Even more surprising was the multitude of Rab proteins identified: 33 in all, more than half of the rat’s genetic inventory (Bock et al., 2001).”