Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock

By N. Steigbigel. Current Infectious Disease Reports, 2003

1,670 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology

View Paper: https://www.semanticscholar.org/paper/b1ad4c015ffaa131acc474de10926d1698746c5d

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In Endocrinology, Diabetes and Metabolism

In Epidemiology

Citations in the corpus

Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003* (2007, background): “Recent advances in the management of sepsis and critically ill patients, such as the use of low-dose corticosteroids for septic shock (40), intensive glucose control (41), the utilization of early goal-directed resuscitation in severe sepsis (42), and drotrecogin alpha (activated) (43), if widely ad”
Pharmacokinetics and Pharmacodynamics of Systemically Administered Glucocorticoids (2005, background): “did not improve mortality,[306,307] but prolonged Such a correlation might be useful to predict the treatment with stress-dose glucocorticoids for days clinical response in patients with focal and segmento weeks was beneficial.[305,308,309] tal sclerosing glomerulonephritis,[316] with kidney transpl”
Melioidosis: Epidemiology, Pathophysiology, and Management (2005, background): “88 Azithromycin (8) and ciprofloxacin (8) vs doxycycline (4) and TMP-SMX (10/50) 12 vs 20 36 vs 29 22 vs 3”
Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine (2008, background): “Although a delta cortisol of 9 g/dL has proven to be an important prognostic marker (9, 53, 93, 94), and a marker of response to treatment with corticosteroids (95, 96), the ACTH stimulation test has a number of limitations.”
American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock (2017, background): “Treatment with low-dose hydrocortisone for relative adrenal insufficiency has gained interest since the first randomized controlled trial (RCT) in adults with septic shock was published in 2002, proving a mortality benefit (276).”
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 (2007, methodology): “Two RCTs demonstrate improved outcome with the use of NIV when it can be employed successfully (162, 165).”
Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine (2009, background): “Administration of prolonged hydrocortisone and fludrocortisone (6 mg/kg/ day cortisol equivalent 7 days) had been recommended for adults with dopamine-resistant septic shock and relative adrenal insufficiency (basal cortisol 18 g/dL with cortisol increment after corticotropin stimulation 9 g/dL) (26”
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012 (2013, methodology): “The RCTs studied mixed populations of surgical and medical ICU patients [128, 328–332] and found that intensive insulin therapy did not significantly decrease mortality [128, 328–332], whereas the NICE-SUGAR trial demonstrated an increased mortality [331].”
Guidelines on Urological Infections (2009, methodology): “Otherwise, staphylococci are not so common in complicated UTIs (0-11%), according to published reports (6,15).”
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference (2003, background): “be more useful for determining whether to institute therapy with hydrocortisone [37].”