Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003*

By Viktor Y. Dombrovskiy, Andrew A. Martin, J. Sunderram, H. Paz. Critical Care Medicine, 2007

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Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations. (2016, background): “(5, 17, 21-36) In this Page 11 of 61 AJRCCM Articles in Press.”
Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. (2012, background): “Severe sepsis is a syndrome of systemic inflammation in response to infection that leads to organ dysfunction, shock, and death in 20%–50% of patients (Dombrovskiy et al., 2007).”
Harmful molecular mechanisms in sepsis (2008, background): “Concluding remarks Despite more than 20 years of extensive research, none of the promising therapeutic approaches for sepsis that target the inflammatory response has been successfully translated to the clinical setting, and rates of sepsis mortality have not decrease”
The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation (2009, background): “Recent estimates indicate that the rate of severe sepsis hospitalizations doubled during the past decade, and the ageadjusted population-based mortality is increasing, resulting in at least 215,000 deaths in the United States yearly (1, 2).”