The hubs of the human connectome are generally implicated in the anatomy of brain disorders

By Nicolas Crossley, Andrea Mechelli, Jessica Scott, Francesco Carletti, Peter T. Fox, Philip K. McGuire, E. Bullmore. Brain : a journal of neurology, 2014

1,096 citations recorded by the source corpus.

See Sporns (doi:10.1093/brain/awu148) for a scientific commentary on this article. Brain networks contain a minority of highly connected hub nodes with high topological value and biological cost. Using network analysis of DTI data from healthy volunteers, and meta-analyses of published MRI studies in 26 brain disorders, Crossley et al. show that lesions across disorders tend to be concentrated at hubs.

Subfields: Cognitive Neuroscience, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/a093f2b05638dd16923434e193c643de32de4eb3

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In Cognitive Neuroscience

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Citations in the corpus

Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment (2023, background): “Regions that are situated centrally in terms of network dynamics may be where functional effects become concentrated and therefore appear to re ﬂ ect focal alterations in neuroimaging studies, despite having a spatially distributed molecular basis [264].”
The theory of constructed emotion: an active inference account of interoception and categorization (2017, positive): “Prolonged imbalances can lead to illness (e.g. Hunter and McEwen, 2013; McEwen et al., 2015) that remodels the brain (Crossley et al., 2014; Goodkind et al., 2015) and the sympathetic nervous system, with corresponding behavior changes (Sloan et al., 2007; Capitanio and Cole, 2015; for a review,…”
Cognitive Network Neuroscience (2015, background): “Damage to cognitive hubs is implicated in many diseases (Crossley et al., 2014) and can result in generalized and catastrophic failures in cognitive function (Warren et al., 2014).”
Morphometric Similarity Networks Detect Microscale Cortical Organisation And Predict Inter-Individual Cognitive Variation (2017, positive): “High degree hub nodes are crucial to the global efficiency of the connectome and preferentially impacted by clinical brain disorders associated with cognitive impairment (Crossley et al., 2014).”