Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall.
By S. Mazmanian, Gwen Liu, H. Ton-That, O. Schneewind. 1999
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Citations in the corpus
- Genome of the Bacterium Streptococcus pneumoniae Strain R6 (2001, background): “aureus, a transpeptidase called sortase anchors exported proteins containing an LPXTG motif followed by a C-terminal hydrophobic domain and a charged tail to the cell wall peptidoglycan (29, 41).”
- Bacterial Secretion Systems – An overview (2016, background): “Targets of SrtA typically contain an N-terminal signal peptide, as well as a 30- to 40-residue C-terminal cell wall sorting signal, which is composed of a pentapeptide cleavage site, LPXTG, and a hydrophobic domain (114, 115).”
- Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues (2009, background): “Sortase A is a transpeptidase that immobilizes 19 surface proteins in the envelope of S. aureus strain Newman ( 13 , 14).”
- Staphylococcus epidermidis – the “accidental” pathogen (2009, background): “MSCRAMMs can be covalently bound to the bacterial surface by sortase”
- Predicting Secretory Proteins with SignalP. (2017, background): “In Gram-positive bacteria, the protein could be attached to the cell wall [8].”
- Coagulase-Negative Staphylococci (2014, background): “It solves the linkage between the amino acids threonine and glycine within the LPXTG sequence and introduces a covalent linkage between the threonine and the peptidoglycan (269, 270).”
- Sortases and the Art of Anchoring Proteins to the Envelopes of Gram-Positive Bacteria (2006, background): “hybrid between enterotoxin B and the protein A cell wall sorting signal (120).”
- Pathogenicity and virulence of Staphylococcus aureus (2021, unknown): “the pentaglycine branch in peptidoglycan [173].”
- Signal Peptide-Dependent Protein Transport inBacillus subtilis: a Genome-Based Survey of the Secretome (2000, background): “During the export of surface proteins, the cell wall sorting signal is cleaved between the Thr and Gly residues of the LPxTG motif by the so-called sortase (SrtA) (169).”