Revisiting the concept of CNS immune privilege
By A. Louveau, Tajie H. Harris, Jonathan Kipnis. Trends in immunology, 2015
594 citations recorded by the source corpus.
Whereas the study of the interactions between the immune system and the central nervous system (CNS) has often focused on pathological conditions, the importance of neuroimmune communication in CNS homeostasis and function has become clear over that last two decades. Here we discuss the progression of our understanding of the interaction between the peripheral immune system and the CNS. We examine the notion of immune privilege of the CNS in light of both earlier findings and recent studies revealing a functional meningeal lymphatic system that drains cerebrospinal fluid (CSF) to the deep cervical lymph nodes, and consider the implications of a revised perspective on the immune privilege of the CNS on the etiology and pathology of different neurological disorders.
Subfields: Cellular and Molecular Neuroscience, Neurology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/b130b9a0a55e062a94c4108639cf663dfa5235c7
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In Cellular and Molecular Neuroscience
In Neurology
Citations in the corpus
- Stress & the gut-brain axis: Regulation by the microbiome (2017, unknown): “Indeed, the immune system may provide a crucial link for microbiota effects on brain physiology and behaviour, perhaps via the recently discovered lymphatic branches within the central nervous system (Louveau et al., 2015).”
- Microglia states and nomenclature: A field at its crossroads (2022, unknown): “Indeed, peripherally produced cytokines and immune cells access the CNSandpatroltheperivascularspaceindiseasebutalsoinhealth, thus playing important roles in coordinating central and peripheral immuneresponses.”
- A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. (2017, unknown): “…to benefit from its resident myeloid cells, microglia, as well as from communication with the systemic immune system (Hanisch and Kettenmann, 2007; Louveau et al., 2015; Quan and Banks, 2007; Schlegelmilch et al., 2011; Schwartz and Shechter, 2010; Sierra et al., 2014; Tremblay 1276 Cell 169,…”
- Astrocyte crosstalk in CNS inflammation (2020, background): “…Interactions with Peripheral Immune Cells during Neuroinflammation The CNS parenchyma is usually considered an ‘immune privileged’ compartment under healthy conditions, which provides limited access to peripheral antibodies and leukocytes (Louveau et al., 2015a; Ransohoff and Engelhardt, 2012).”