Analytical applications of aptamers.

By S. Tombelli, M. Minunni, M. Mascini. Biosensors & bioelectronics, 2005

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SELEX--a (r)evolutionary method to generate high-affinity nucleic acid ligands. (2007, methodology): “The use of affinity chromatography with immobilization of target on column material like sepharose or agarose is a conventional method for this separation step (Liu and Stormo, 2005; Tombelli et al., 2005a).”
Biosensors and nanomaterials and their application for mycotoxin determination (2011, background): “Interest in the use of aptamers has increased in recent years especially for use as sensing molecules in the area of diagnosis (Luzi et al., 2003; Tombelli et al., 2005).”
Electrochemical Biosensors - Sensor Principles and Architectures (2008, background): “In this approach suitable binding sequences are first isolated from large oligonucleotide libraries and subsequently amplified [6, 232].”
Aptamers and Their Biological Applications (2012, background): “However, these membranes have some limitations, such as being incapable of binding small molecules and peptides, and they generally require at least 12 selection rounds [18,19].”