SELEX--a (r)evolutionary method to generate high-affinity nucleic acid ligands.

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A Review on Biosensors and Recent Development of Nanostructured Materials-Enabled Biosensors (2021, methodology): “By an in vitro selection mechanism, SELEX (Systematic Evolution of Ligands by EXponential enrichment), aptamers can be isolated from oligonucleotides libraries [54,55].”
Electrochemical biosensors for pathogen detection (2020, background): “Iqbal et al. performed 10 rounds of SELEX to discover 14 aptamer clones with high affinities for C. parvum for detection in fruit samples (Iqbal et al. 2015).”
A census of human RNA-binding proteins (2014, background): “Exponential Enrichment) RNA ligand selections (Stoltenburg et al., 2007), enabled researchers to”
Emerging applications of label-free optical biosensors (2017, background): “A vast spectrum of biomolecular recognition elements is offered by nature and, if not already available, various biotechnology strategies can be exploited to produce novel biomolecules capable of binding virtually any possible compound [3, 4].”