Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart

By H. Ott, Thomas S Matthiesen, Saik-Kia Goh, Lauren D. Black, S. Kren, Theoden I. Netoff, Doris A Taylor. Nature Medicine, 2008

2,618 citations recorded by the source corpus.

Subfields: Biomaterials, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/b0eb88426a43ccec6e9e4e44ad7761c4454fc403

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Citations in the corpus

Complexity in biomaterials for tissue engineering. (2009, background): “In a further development, last year's transplanted TE airway confirmed this approach as being at the forefront of whole-organ tissue engineerin”
Intrinsic extracellular matrix properties regulate stem cell differentiation. (2010, background): “For both embryonic and adult stem cells, ECM properties, including (1) structural (Dalby et al., 2007; McBeath et al., 2004), (2) biochemical (Helen et al., unpublished; Ott et al., 2008), and (3) mechanical (Engler et al., 2006; McBeath et al., 2004; Ruiz and Chen, 2008) cues, develop in concert.”
The Case for Dynamic Models of Learners' Ontologies in Physics (2008, background): “Recently, researchers have been able to grow in the laboratory a heart that exhibits normal heart contractions without being attached to the rest of the circulatory system (Ott et al., 2008).”
FTIR analysis of natural and synthetic collagen (2018, background): “gen-based biomaterials are leading materials for cardiovascular regenerative medicine (16, 17).”
The use of whole organ decellularization for the generation of a vascularized liver organoid (2011, methodology): “Alternatively, previous methods to recellularize organ scaffolds have relied heavily on direct cell injection, that damaged the scaffold microarchitecture and produced heterogeneous scaffold seeding.(13) The perfusion method introduced here supports cell infusion through the vascular network and dep”
Organ-on-a-Chip Platforms for Studying Drug Delivery Systems (2014, background): “Additionally, to recreate a functional cardiac tissue, scaffolds can be used to recreate 3D tissue architecture [79].”
Nanotopography-guided tissue engineering and regenerative medicine (2012, result): “This is similar to the mechanics of native heart tissue [188].”
Emerging trends and new developments in regenerative medicine: a scientometric update (2000 – 2014) (2014, methodology): “2008 Perfusion-decellularized matrix: using nature’s platform to engineer a bioartificial heart NAT MED [67]”
Current advances and future perspectives in extrusion-based bioprinting. (2016, background): “Taylor's groundbreaking work in organ decellularization [178] has attracted numerous researchers in the last five years in the regeneration of organs such as the heart [179], kidney [180], liver [181], cartilage and bone [182], pancreas [183] and others [7,184].”
Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation. (2012, background): “In fact, prior studies using decellularized heart (15), bone (38), and murine lung (39) as matrices to support regeneration imply these features remain true to the native organ, although this has not been directly shown previously.”